from cryptography.hazmat.backends import default_backend
from cryptography.hazmat.primitives.asymmetric import rsa
private_key = rsa.generate_private_key(
    public_exponent=65537,
    key_size=2048,
    backend=default_backend()
)

# Sign a message using the key
from cryptography.hazmat.primitives import hashes
from cryptography.hazmat.primitives.asymmetric import padding
message = b"A message I want to sign"
signature = private_key.sign(
    message,
    padding.PSS(
        mgf=padding.MGF1(hashes.SHA256()),
        salt_length=padding.PSS.MAX_LENGTH
    ),
    hashes.SHA256()
)